Sarepta Therapeutics Inc (NASDAQ:SRPT) is down 23.2% to trade at $77.86 at last check, and earlier hit a 52-week low of $75.06. The security is pacing for its worst single-day percentage loss since October 2023 after the gene-editing company revealed a 16-year-old boy died from acute liver failure after receiving its gene therapy for a rare muscular dystrophy. Year to date, the equity is down 37.5%. 

Beam Therapeutics Inc (NASDAQ:BEAM) is down 6.8% to trade at $22.85 at last glance, brushing off a price-target hike from Leerink Partners to $42 from $37. The shares are track for their third loss in four sessions, and earlier today slipped to their lowest level since January, as they test the supportive $22 level. The 20-day moving average has acted as resistance so far this month, and in the last 12 months the stock shed over 32%. 

Crispr Therapeutics AG (NASDAQ:CRSP) was last seen down 4.6% to trade at $40.87. A floor at $40 looks ready to contain today's losses, after stopping a pullback form the equity's highest level since November. Though overhead pressure at the 100-day moving average remains and shares carry a 42.6% year-over-year deficit, so far in 2025 they have added 4%.

The Dow Jones Industrial Average (DJI) and Nasdaq Composite (IXIC) are poised to resume losses today, with both indexes sporting triple-digit midday losses as pessimism bites back. The S&P 500 Index (SPX) is also lower this afternoon, inching back towards correction territory as the Federal Reserve's two-day policy meeting kicks off. Per the CME's FedWatch tool, Fed funds futures are pricing in a 99% chance of interest rates holding steady.

Continue reading for more on today's market, including: 

• Energy stock pops on "clean coal" buzz.
• Analyst: Duolingo subscriptions could grow.
• Plus, TME's post-earnings pop; why Mosaic stock is surging; and cruise stock sailing lower.

Tencent Music Entertainment Group (NYSE:TME) stock is getting hammered in the options pits today, with 12,000 calls and 2,635 puts exchanged so far, which is 10 times the volume typically seen at this point. The most active contract is the March 15 call, but new positions are being opened at the October 21 call. TME was last seen 8.4% higher to trade at $14.15, after the China-based concern unveiled upbeat annual and fourth-quarter results. TME is pacing for a fifth-straight gain, and earlier surged to its highest level since July. In the last six months, TME added 50.7%.

Mosaic Co (NYSE:MOS) stock is one of the best performers on the SPX today, last seen up 2.8% to trade at $27.26, amid the company's Analyst Day. MOS could nab its fourth consecutive gain in today's session, as it moves back above the 40-day moving average. Shares are extending a bounce off their March 4, four-year low of $22.48, and have added more than 11% so far in 2025.

Royal Caribbean Cruises Ltd (NYSE:RCL), meanwhile, is among the worst stocks on  on the SPX today, last seen down 6.9% to trade at $204.22, looking to snap a four-day win streak. While a catalyst for today's negative price action remains unclear, shares have been sailing lower on the charts since a Jan. 31, record high of $277.08. A familiar floor at $200 could contain losses, and longer term RCL still boasts a 59.2% year-over-year lead.

Retail stock Ralph Lauren Corp (NYSE:RL) received an upgrade from Goldman Sachs to "buy" from "neutral" this morning, with a price-target hike to $286 from $280. The firm cited the New York-based company's limited exposure to tariffs in comparison to its peers in the fashion industry. Meanwhile, reports show Raymond James bought up 72,942 shares of RL in the fourth quarter, which amounts to over $16 million. Despite the lofty upgrade, RL was last seen only 0.5% higher to trade at $220.96, paring larger premarket gains. 

On the charts, the stock has yet to recover from an extended slide in early March, though the 160-day moving average has provided a floor for the past week. Now much further removed from their Feb. 6 record high of $289.33, the shares are down 4.4% year-to-date. 

After RL's most recent pullback, its 14-day relative strength index (RSI) checked in at 21.7 last night, firmly in "oversold" territory, which typically precedes a short-term bounce. Plus, short interest now represents 4.9% of the stock's available float, so keep an eye out for a short squeeze going forward.

Options bulls appear to be targeting RL straight out of the gate this morning. The stock has seen eight times the call volume typically seen at this point, with the most activity at the March 230 call. 

Duolingo Inc (NASDAQ:DUOL) stock is up 0.8% at $296.39 at last check, after JMP Securities upgraded the language-learning platform to "outperform" from "market perform." The firm pointed to the potential growth of Duolingo Max subscriptions as a key driver for future gains, while also highlighting the stock’s attractive valuation as a bullish catalyst.

On the charts, DUOL is still struggling with the $300 level, which moved in as resistance following a steep 17% post-earnings pullback in late-February. The security has also been struggling with pressure from its 100-day moving average, and is down 9.3% since the start of 2025.

Coming into the session, nine of 17 covering brokerages rated the security a "hold," which leaves room for even more upgrades to roll in. Meanwhile, options traders are more bullish, per DUOL's Schaeffer's put/call open interest ratio (SOIR) of 0.58, which sits in the lowest possible percentile of reading from the past 12 months. 

Options are an intriguing way to bet on the stock right now, as it tends to outperform volatility expectations. This is per Duolingo stock's Schaeffer's Volatility Scorecard (SVS), which sits at an elevated 83 out of 100.  

Darden Restaurants Inc (NYSE:DRI) stock was last seen up 0.9% to trade at $187.70, bouncing off a pullback to its lowest level since January after it hit a March 3, record high of $203.12. In addition to sporting a nine-month lead of 22.2%, the shares are now within striking distance of a trendline that has historically produced bullish returns.

All eyes are on Nvidia Corp (NASDAQ:NVDA) stock this week, as the annual GTC conference -- the company's biggest artificial intelligence (AI) and tech summit-- kicks off tomorrow. Ahead of the event, NVDA is 2.6% lower to trade at $118.47, succumbing to broader-market pressure as the Nasdaq remains entrenched in correction territory. Last year during GTC week though, the shares gained 7.4%, and that may be all call traders needed to hear.

Despite a 11% deficit year-to-date, Nvidia stock has remained popular among options traders, landing the top spot on Schaeffer's Senior Quantitative Analyst Rocky White's list of stocks with the highest options volume in the past 10 days. In this period, over 36.3 million calls and 21.9 million puts were exchanged, numbers that almost double the number of Tesla (TSLA) options traded.

The weekly 3/14 120-strike call was the most popular in the last two weeks, while April and June 120-strike calls saw 100,000 contracts fly off the shelves on March 5, a sign of possible spread activity. On the charts, keep an eye on the stock's 320-day moving average, a trendline that tested and caught last week's pullback.

Now looks like an great time to weigh in with options. NVDA's Schaeffer's Volatility Index (SVI) of 66% sits in the 17th percentile of its annual range, indicating implied volatilities are favorable for premium traders at the moment. 

Quantum computing stocks soared on Friday as traders targeted tech stocks amid the broader market rebound. Nvidia's (NVDA) semi-annual GTC conference -- hailed as a top artificial intelligence (AI) event -- is putting the sector back in the spotlight as well. Per the company, CEO Jensen Huang plans to discuss what's next in agentic AI, robotics, accelerated computing, and more during his keynote speech tomorrow. 

D-Wave Quantum Inc (NYSE:QBTS) stock is extending last session's 46.9% bounce, up 8.4% at $11.01 at last glance. Earlier today, QBTS came one cent shy of its Dec. 27, two-year high of $11.40. On track for its fifth-straight daily gain, the equity is up 425.5% year over year and 30.1% year to date. 

IonQ (NYSE:IONQ) was last seen down 2.4% at $24.39, pulling back after Friday's 17% pop. The 20-day moving average, which resides at $25, appears to have capped recent gains. Since the start of 2025, the equity is underperforming with a 41.4% deficit. 

The shares of Rigetti Computing Inc (NASDAQ:RGTI) are down 2.5% at $10.94 at last glance, following last session's 28.2% surge. The 60-day moving average -- a trendline that caught RGTI's January pullback but was breached in late February -- is providing overhead pressure. Year to date, the equity is down 27.7%.